Imatinib binds to an intracellular pocket located within tyrosine kinases tk, thereby inhibiting atp binding and preventing phosphorylation and the subsequent activation of growth receptors and their downstream signal transduction pathways. Daily dosing of 800 mg and above should be accomplished using the 400 mg tablet to reduce exposure to iron. With the advent of a range of generic drugs on the market, you may not be dispensed gleevec imatinib mesylate tablets unless your physician determines that branded gleevec is appropriate for you and expressly marks your prescription with a daw dispense as written. Imatinib mesylate is orally bioavailability mesylate salt of imatinib, which is a multitarget inhibitor of vabl, ckit and pdgfr with ic50 of 0. Acute lymphoblastic leukemia in adults and children that is philadelphia chromosome positive. Gleevec the following information is not intended to endorse any particular medication. Imatinib mesylate im is the first developed protein kinase inhibitor and recently it has topped consumption rates among targeted and total anticancer drugs. Read complete imatinib mesylate msds matnib manufactured by getwell oncology a leader manufacturing complex oncology generics in india. Material safety data sheet article 1 identification of the substance and of the companyundertaking product name. Imatinib is a drug used to treat certain types of cancer. Currently there are no citations for imatinib mesylate. It is not to be used in diagnostic, therapeutic, consumer, agricultural, nor pesticidal applications. However, adverse events in cancer patients are significantly under reported and a large proportion of patients treated with imatinib mesylate have had limited followup thus not permitting a final analysis of the potential for an increased incidence of a secondary malignancy.
Efficacy and safety of imatinib mesylate in advanced. Imatinib is an inhibitor of the receptor tyrosine kinases cabl, bcrabl, pdgfr, and ckit. Imatinib mesylate api manufacturers suppliers drug. Imatinib mesylate is a tyrosine kinase inhibitor ic50 value of 100 nm, 100 nm, 600 nm for vabl, ckit, pdgfr, respectively 1.
A methanesulfonate mesylate salt that is the monomesylate salt of imatinib. View detailed export data, price, monthly trends, major exporting countries, major ports of imatinib mesylate under hs code 2933. Imatinib is a potent inhibitor of the bcrabl kinase encoded by the bcrabl oncogene as well as receptor tyrosine kinases encoded by ckit and plateletderived growth factor receptor pdgfr oncogenes. During all fire fighting activities, wear appropriate protective equipment, including self contained breathing apparatus. Export data and price of imatinib mesylate under hs code. Material safety data sheet of imatinib mesylate contains identification of substance and details of the supplier of the safety data sheet. Imatinib mesylate is a kinase inhibitor indicated for the treatment of.
Material safety data sheet tarcevar tablets 25 mg section 1. Skin contact wash off immediately with plenty of water for at least 15 minutes. Imatinib mesylate, a selective tyrosine kinase inhibitor, has been shown in preclinical models and preliminary clinical studies to have activity against such tumors. We will use secondary reference standards previously referred to as working standard for direct control of. Sigmaaldrich offers a number of imatinib mesylate products. Firstaid measures eye contact rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.
Highlights of prescribing information these highlights do not include all the information needed to use gleevec safely and effectively. Articles of imatinib mesylate are included as well. This is the actual form of the drug sold as gleevecglivec. During all fire fighting activities, wear appropriate protective equipment, including self. No component of this product present at levels greater than or equal to 0. Imatinib mesylate is a pill, taken by mouth, once or twice daily.
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors article pdf available in new england journal of medicine 3477. Repeatdose studies in animals have shown a potential to cause adverse effects on blood. Store in accordance with information listed on the product insert. Do you know of a great paper that uses imatinib mesylate from tocris. Product identifier product name tarcevar tablets 25 mg product code sap10077703 synonyms tarceva f. Imatinib mesylate is a white to offwhite to brownish or yellowish tinged crystalline powder. In cellular assays, imatinib accelerates erythroblast differentiation and inhibits melanogenesis. Imatinib mesylate investigated as a drug, reproductive effector and tumorigen. Matnib, imatinib mesylate tablets, imatinib mesylate manufacturer, imatinib mesylate manufacturer in india, imatinib mesylate price in india, imatinib mesylate cost in india, imatinib mesylate.
The amount of imatinib mesylate that you will receive depends on many factors, including your general health or other health problems, and the type of. We conducted an openlabel, randomized, multicenter trial to evaluate the activity of imatinib in patients with advanced gastrointestinal stromal tumor. Imatinib mesylate is not a pharmacopoeia product and as such primary reference standards for imatinib mesylate are not available from recognized pharmacopoeias. In nonaqueous solvents, the compound is soluble in dimethyl sulfoxide, methanol and ethanol, but is. Identification of the substancemixture and of the companyundertaking 1. Imatinib is an anticancer chemotherapeutic compound that inhibits abl, ckit, and pdgfr. Potent and selective vabl tyrosine kinase inhibitor. A designer drug inusha panigrahi, r naithani abstract molecularly targeted therapy is a novel approach in cancer treatment. In adults, it is used for disease that has recurred come back or is refractory does not respond to treatment.
Keywords matnib, imatinib mesylate tablets, imatinib mesylate manufacturer, imatinib mesylate manufacturer in india, imatinib mesylate price in india, imatinib mesylate cost in india, imatinib mesylate. Aug 05, 2019 increase imatinib dosage by at least 50% and carefully monitor clinical response in patients receiving concomitant therapy with imatinib and potent cyp3a4 inducers e. Imatinib mesylate is a tyrosine kinase inhibitor with antineoplastic activity. Gleevec imatinib mesylate tablets, for oral use initial u.
Article 1 identification of the substance and of the companyundertaking. Imatinib mesylate is a proteintyrosine kinase inhibitor that inhibits the bcrabl tyrosine kinase, the constitutive abnormal tyrosine kinase created by the philadelphia chromosome abnormality in chronic myeloid leukaemia cml. Identification of the substancemixture and of the company. Aug 15, 2002 imatinib mesylate, a selective tyrosine kinase inhibitor, has been shown in preclinical models and preliminary clinical studies to have activity against such tumors. Pdf efficacy and safety of imatinib mesylate in advanced. Imatinib mesylate sti571 mesylate is a tyrosine kinases inhibitor that inhibits ckit, bcrabl, and pdgfr ic50100 nm tyrosine kinases. The beta crystalline form of the molecule is a specific polymorph of imatinib mesylate. Tyrosine kinase is an enzyme which is a subclass of protein kinase and plays an important role in transferring a phosphate group from atp to a protein in cells. Imatinib mesylate revision date 23jan2018 imatinib mesylate 220127571 95 4. Known hypersensitivity to imatinib or any ingredient in the formulation. Its molecular formula is c29h31n7o x ch4so3 and its molecular weight is 589. Take this medication by mouth with a meal and a full glass of water 8 ounces240 milliliters as directed by your doctor, usually once or twice daily. First aid measures eye contact if this product comes in contact with the eyes.
Imatinib mesylate is a white to slightly yellowish powder. The amount of imatinib mesylate that you will receive depends on many factors, including your general health or other health problems, and the type of cancer or condition being treated. Material safety data sheet of imatinib mesylate abmole. Imatinib mesylate is the mesylate salt of imatinib, a tyrosine kinase inhibitor with antineoplastic activity. Imatinib, a specific tyrosine kinase inhibitor, since its inception in 1990s, has become the firstline drug in management of. See actual entry in rtecs for complete information. Material safety data sheet of imatinib mesylate abmole bioscience. Imatinib mesylate should be taken with a large glass of water, after a meal. It is occasionally referred to as cgp57148b or sti571 especially in older publications. Imatinib mesylate is a small molecule that inhibits the cabl proteintyrosine kinase, a kinase specifically important for proliferation of chronic myelogenous leukemia cml. Imatinib mesylate cgp57148b, sti571 emergency overview. Used for treatment of chronic myelogenous leukemia and gastrointestinal stromal tumours. Targets vabl pdgfr ckit ic50 600 nm 100 nm 1 100 nm 2 in vitro.
Citations are publications that use tocris products. In children, it is used with chemotherapy as the first treatment after the disease is diagnosed. Safety data sheet imatinib mesylate effective date. Sds of imatinib mesylate, safety data sheets, cas 220127571. Adobe acrobat reader is required to reliably view, print and comment on pdf documents imatinib mesylate product citations. Highlights of prescribing information prescribing information. It is currently marketed by novartis as gleevec usa or glivec europeaustralia as its mesylate salt, imatinib mesilate inn. Increase imatinib dosage by at least 50% and carefully monitor clinical response in patients receiving concomitant therapy with imatinib and potent cyp3a4 inducers e. Only select registry of toxic effects of chemical substances rtecs data is presented here.
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